Antibiotic treatment effective for most common gastrointestinal disorder in U.S., research shows 

ANN ARBOR, Jan. 6, 2011: — A ground-breaking antibiotic therapy is the first potential drug treatment to provide Irritable Bowel Syndrome (IBS) patients with long-lasting relief of their symptoms even after they stop taking the medication, according to a study published in the Jan. 6, 2011 issue of the New England Journal of Medicine.   

Unlike other traditional therapies for IBS, patients in these large studies reported relief of their symptoms for up to 10 weeks after completing treatment with rifaximin, says William D. Chey, M.D., professor in the Department of Internal Medicine at the University of Michigan.   

Rifaximin is a minimally absorbed antibiotic that stays in the gut. Specifically, patients reported improvement in overall IBS symptoms, relief from bloating, less abdominal pain and improved stool consistency for up to 10 weeks, says Chey, one of the researchers on the study and director of the Michigan Bowel Control Program. 

While the concept of bacteria playing a key role in this condition was controversial when first introduced a decade ago, this research confirms that bacteria in the gut, also known as the “gut microbiome,” plays a role in the symptoms of IBS, a chronic condition affecting an estimated 30 million people in the United States. The therapy was developed at Cedars-Sinai Medical Center.   

These findings show that targeted antibiotics provide safe and effective long-lasting relief for this condition, says Mark Pimentel, M.D., GI Motility Program director and principal investigator of the clinical trials at Cedars-Sinai.   

“This represents a big change in the way we think about and treat IBS,” says U-M’s Chey, adding that IBS often does not respond well to treatments currently available like dietary changes or fiber supplements alone. Patients also often see a return of symptoms once traditional medical treatments are stopped. But with this new treatment, the patients feel better and continue to feel better after stopping the drug. 

In two, 600-plus patient double-blind trials, IBS patients with mild to moderate diarrhea and bloating were randomly assigned to take a 550 milligram dose of rifaximin or placebo three times daily for two weeks. Study participants were then followed for 10 weeks more. About 40 percent of patients who took the drug reported they had significant relief from bloating, abdominal pain and loose or watery stools. Further, that relief was sustained for weeks after completing treatment with the antibiotic. 

Doctors commonly categorize IBS patients with a “constipation predominant” condition, a “diarrhea-predominant”  condition, or a mixed pattern of diarrhea and constipation. In addition, patients often experience abdominal pain or cramps, excess gas or bloating, and visible abdominal distension. 

Because the cause of the disease had been elusive, treatments for the disease historically have focused on relieving its symptoms with medications that either slow or speed up the digestive process. Earlier research documents a link between bloating, the most common symptom, and bacterial fermentation in the gut related to small intestine bacterial overgrowth, or SIBO. Other research has suggested that the bacteria which reside within the small and large intestines of IBS patients may be different than those inhabiting the intestines of healthy individuals. 

Rifaximin is approved by the U.S. Food and Drug Administration to treat travelers’ diarrhea and hepatic encephalopathy.   

Besides Cedars-Sinai and U-M, other centers participating in the clinical trials included Beth Israel Deaconess Medical Center in Boston, University of North Carolina at Chapel Hill, and Connecticut Gastroenterology Institute in Bristol, Conn. 

Rifaximin is marketed by Salix Pharmaceuticals Inc. Salix also provided funding for the studies. Pimentel discovered the use of rifaximin for IBS, and Cedars-Sinai holds patent rights to this discovery and has licensed rights of the invention to Salix. Dr. Pimentel is a consultant to Salix, Inc, and serves on its scientific advisory board. 

About the University of Michigan’s division of gastroenterology: U-M has one of the largest gastroenterology practices in the country and is a leader in the prevention, diagnosis, and treatment of diseases of the gastrointestinal tract and liver. Our 50-plus physicians are experts in the diagnosis and treatment of all diseases of the gastrointestinal system, from simple to complex, including those of the esophagus, stomach, small intestine, colon, rectum, liver, gallbladder, pancreas and biliary tract. 

In addition to being leaders in the clinic, our faculty are also leaders in their respective areas of research, which span such varied interests as the role of peptides in the brain-gut interactions in functional bowel diseases to innovative treatments of viral hepatitis and liver cancer.

Un tratamiento con antibióticos es el más eficaz para un trastorno gastrointestinal común en Estados Unidos, según una investigación

ANN ARBOR, el 6 de enero del 2011: Una terapia innovadora con antibióticos es el primer tratamiento potencial con medicamentos que proporciona a los pacientes con el síndrome de intestino irritable (SII) un alivio duradero de sus síntomas aún después que dejan de tomar los medicamentos, según un estudio publicado en la edición del 6 de enero de la revista New England Journal of Medicine.

A diferencia de otros tratamientos tradicionales para el síndrome de intestino irritable, los pacientes en estos estudios extensos dieron cuenta de alivio de sus síntomas por hasta diez semanas después que completaron el tratamiento con Rifaximin, dijo William D. Chey, profesor en el Departamento de Medicina Interna de la Universidad de Michigan.

      Rifaximin es un antibiótico de absorción mínima que permanece en los intestinos. Específicamente los pacientes dieron cuenta de una mejoría en los síntomas generales del SII, alivio de la hinchazón, menos dolor abdominal y una mejor consistencia de la materia fecal por hasta diez semanas, dijo Chey, uno de los investigadores que participaron en el estudio y director del Programa de Control Intestinal de Michigan.

      Si bien el concepto de que las bacterias desempeñan un papel clave en esta condición era controvertido cuando se introdujo hace una década, esta investigación confirma que las bacterias en los intestinos, conocidas también como el microbioma intestinal, desempeña un papel en los síntomas del SII, una condición crónica que afecta a unos 30 millones de personas en Estados Unidos. La terapia se desarrolló en el Centro Médico Cedars Sinaí.

      Estas conclusiones muestran que los antibióticos específicos proporcionan un alivio seguro, eficaz y duradero para esta condición, dijo Mark Pimental, director del Programa de Motilidad e investigador principal de las pruebas clínicas en Cedars Sinaí.

      “Esto representa un gran cambio en la forma en que pensamos acerca del SII y la forma en que lo tratamos2, dijo Chey, de la UM, añadiendo que el SII a menudo no responde bien a los tratamientos disponibles actualmente como los cambios en la dieta o los suplementos con fibra por sí solos. Los pacientes también ven a menudo un retorno de los síntomas una vez que terminan los tratamientos médicos tradicionales. Pero con este nuevo tratamiento los pacientes se sienten mejor y continúan sintiéndose mejor después que ya no toman el medicamento.

      En dos pruebas dobles ciegas con 600 pacientes, a los pacientes de SII con diarrea de liviana a moderada e inflamación se les  asignó al azar una dosis de 550 miligramos de Rifaximin o un placebo, tres veces por día durante dos semanas. Se observó a los participantes del estudio durante diez semanas más. Aproximadamente el 40 por ciento de los pacientes que tomaron el medicamento dieron cuenta de un alivio significativo en la inflamación, el dolor abdominal y de la materia fecal floja o líquida. Además el alivio se mantuvo por semanas después que se completó el tratamiento con el antibiótico.

      Los médicos comúnmente categorizan a los pacientes de SII con una condición de “constipación (o estreñimiento) predominante” o una condición de “diarrea predominante”, o un patrón mezclado de diarrea y constipación. Además los pacientes a menudo experimentan dolores y calambres abdominales, exceso de gas o hinchazón y una distensión abdominal visible.

      Dado que no se ha podido determinar todavía la causa de la enfermedad, los tratamientos para el mal históricamente se han enfocado en el alivio de los síntomas con medicamentos que hacen más lento o aceleran el proceso digestivo. Hay documentación de investigación anterior que vincula la hinchazón, que es el síntoma más común, con la fermentación bacterial en los intestinos relacionada con un crecimiento bacterial excesivo en el intestino delgado. Otra investigación ha sugerido que las bacterias que residen en el intestino grueso y el intestino delgado de los pacientes de SII pueden ser diferentes de las que habitan en los intestinos de los individuos saludables.

      Rifaximin está aprobado por la Dirección de Alimentos y Medicamentos (FDA por su sigla en inglés) de Estados Unidos para el tratamiento en los viajeros de la diarrea y la encefalopatía hepática.

      Además de Cedars Sinaí y la UM otros centros que participaron en las pruebas clínicas incluyen el Centro Médico Beth Israel Deaconess en Boston; la Universidad de Carolina del Norte en Chapel Hill, y el Instituto Connecticut de Gastroenterología en Bristol, Connecticut.

      Rifaximin lo comercializa la firma Salix Pharmaceuticals, Inc. Salix también proporcionó los fondos para los estudios. Pimentel descubrió el uso de Rifaximin para el CII, y Cedars Sinai tiene los derechos de patente sobre este descubrimiento y ha otorgado derechos de licencia de la invención a Salix. Pimentel es un consultor de Salix y forma parte de su consejo asesor científico.

      Acerca de la división de gastroenterología de la Universidad de Michigan. La UM tiene una de las prácticas de gastroenterología más grandes del país y es pionero en la prevención, diagnóstico y tratamiento de las enfermedades del sistema gastrointestinal y el hígado. Nuestros más de 50 médicos son expertos en el diagnóstico y el tratamiento de todas las enfermedades del sistema gastrointestinal, desde las más simples a las más complejas, incluidas las enfermedades del esófago, estómago, intestino delgado, clon, recto, hígado, vesícula biliar, páncreas y tracto biliar.

      Además de ser pioneros en la clínica nuestros docentes también están en la vanguardia de sus respectivas áreas de investigación que incluyen intereses tan variados como el papel de los péptidos en las interacciones del cerebro y los intestinos en las enfermedades que afectan el funcionamiento intestinal y los tratamientos innovadores de la hepatitis viral y el cáncer de hígado.

We'd like to know what you think about this article. Please leave your comments below so we can share your thoughts with other visitors. 

louis vuitton outlet

[email protected]

Friday, October 26, 2012

When you visit one of the outlets of the Louis you http://www.louissvuittonoutlethandbags.com can see fabulous collection of designer handbags of various size, shape and colors kept for display. But one cannot http://www.cheap-louisvuittonoutlets.net choose all of them. One has to look for quality leather while shopping for any other brands except Louis Vuitton since all the products manufactured by them are of superior quality. Just touch the bag and you can judge the difference in leather quality between a Louis handbag and other brands. Decide the size and price of the fashion handbag which you wish to buy, before you leave the house. Otherwise, you may end up spending more http://www.louisvuittonhandbags-outlet-bags.com than your budget, on seeing the extraordinary collection of bags in the outlet.

alice

[email protected]

Friday, April 06, 2012

http://theshoppingshoes.com/christian-louboutin-romaine-140-platform-sandals-suede-p-233.html Christian Louboutin Romaine 140 Platform Sandals Suede , http://theshoppingshoes.com/christian-louboutin-ambertina-bejeweled-sandal-p-221.html Christian Louboutin Ambertina Bejeweled Sandal , http://theshoppingshoes.com/christian-louboutin-jean-paul-120-wedge-sandals-p-239.html Christian Louboutin Jean Paul 120 wedge sandals , http://theshoppingshoes.com/christian-louboutin-black-suede-larissa-plato-platform-sandal-p-251.html Christian Louboutin black suede 'Larissa Plato ' platform sandal , http://theshoppingshoes.com/christian-louboutin-leopard-wedges-p-228.html Christian Louboutin Leopard Wedges , http://theshoppingshoes.com/christian-louboutin-tigresse-140-leather-wedges-p-242.html Christian Louboutin Tigresse 140 leather wedges

If best sunglasses that seems a bit much for your store, a collage of tabloid items might work better. http://www.bestdiscountsunglasses.net |wholesale sunglasses http://www.bestdiscountsunglasses.net |best sunglasses http://www.bestdiscountsunglasses.net |designer sunglasses http://www.bestdiscountsunglasses.net |discount sunglasses

[email protected]

Thursday, April 05, 2012

If best sunglasses that seems a bit much for your store, a collage of tabloid items might work better. http://www.bestdiscountsunglasses.net |wholesale sunglasses http://www.bestdiscountsunglasses.net |best sunglasses http://www.bestdiscountsunglasses.net |designer sunglasses http://www.bestdiscountsunglasses.net |discount sunglasses

Coach Factory Outlet

[email protected]

Thursday, March 29, 2012

http://www.coachfactory-outletonlines.net http://www.cheap-vouisvuittonbagso.net http://www.coachoutletstores-onlinez.net http://www.louisvuitton-bags-2012.net http://www.coachoutletsonline-usa.com http://www.louisvuitton-outlet-2012.net

nike shox for cheap

[email protected]

Wednesday, March 21, 2012

Carried on the back a short while, Tang Jin <a href="http://www.pickshoxsneaker.com"><b>nike shox outlet</b></a> stood to start,the body presses formula for incantation up say of stat acting, "I vigorously already connect go into that strength, just not behind not and first such as;Skin Ran fire, gush such as the spring"not the kid of the distance Lei <a href="http://www.pickshoxsneaker.com"><b>cheap shox sale</b></a> Lei just from listTang Jin of Chang salty  Long  Chun 鹀 ao field the center is unexpectedly hands to embrace to circulate to row a circle before the chest, not from must stunnedly"Yi"1, is it too very to wish him how can anyone know <a href="http://www.pickshoxsneaker.com/nike-shox-nz-mens-shoes-c-1.html"><b>nike shox nz women's shoes</b></a> this?Tang vigorously shut eyes to beat a burst of, although don't know oneself why wants to do like this, however effect but is very obvious, have fever unclearly all over now, so coldly sky, this <a href="http://www.pickshoxsneaker.com/nike-shox-nz-mens-shoes-c-1.html"><b>nike shox nz for sale</b></a> formula for incantation is to can not completely appreciate confessedly by himself/herself, it makes the strong elder brother seeks a superior again next time and lets him advises for a <a href="http://www.pickshoxsneaker.com/cheap-nike-shox-nz-shoes-for-men-white-gold-p-37.html"><b>nike shox nz running shoes</b></a> while and wait to do duel with effeminate man!Age:17 heights:166 cm publishes an album:《Remember that day 》 of 《the meteor allows a promise 》《breeze bell myth 》 AILSA is <a href="http://www.pickshoxsneaker.com/cheap-nike-shox-nz-shoes-for-men-white-gold-grey-p-38.html"><b>nike shox nz shoes</b></a> most redly arecent years domestic singer, July, last year, 《meteor Xu Nuo 》 allows this beautiful girl to make numerous fans for of the fanaticism , after album comes out, is also <a href="http://www.pickshoxsneaker.com/cheap-nike-shox-nz-shoes-for-men-white-gold-yellow-p-39.html"><b>shox nz shoes</b></a> that the widely popular big river is southern northern, can hear her only beautiful singing everywhere, situation temporarily have no two.The second 《remember that day 》 of album of <a href="http://www.pickshoxsneaker.com/cheap-nike-shox-nz-shoes-for-men-white-grey-black-p-40.html"><b>free shipping shox</b></a> the publication ground and 《breeze bell myth 》 in the end of the year win this annual recorrankinrespectivelyatthebeginning of this year ten greatly popular album ground in the 1, 2th place is it may be said a miracle.

nike shox oulet

[email protected]

Monday, March 19, 2012

our children will likely be far more willing to sit down and read an ebook together. nike shox| http://www.womennikeshoxoutlet.com nike shox shoes| http://www.womennikeshoxoutlet.com nike shox oulet| http://www.womennikeshoxoutlet.com women nike shox| http://www.womennikeshoxoutlet.com nike shox NZ| http://www.womennikeshoxoutlet.com nike shox sale| http://www.womennikeshoxoutlet.com

xuefei

[email protected]

Tuesday, February 28, 2012

http://www.macvobconverter.net vob converter mac is 2010 the hottest software which is very popular among mac users who want to convert VOB to other video formats on mac like MP4, AVI, WMV, MPG, MPEG, MOV, TS, FLV, etc. With super fast conversion speed and high output quality, it can ensure you a fluent process to convert VOB mac. http://www.movconvertermac.net mov converter mac is a very powerful conversion software specially designed for Mac users. This all-in-one DVD Ripper for Mac and Video Converter for Mac not only can rip DVD video to all popular video formats such as AVI, MOV, MP4, M4V, ASF, but also convert all sorts of video formats to MOV format. How to Convert AVI to MP4 on Mac? Now I recommend a software for you that can help you to Convert http://www.avitomp4mac.net AVI to MP4 Mac.This AVI to MP4 Mac is widely used by mac users . you can enjoy the most wonderful video file anywhere and anytime whith the AVI to MP4 Mac . http://www.flvtomp3mac.com flv to mp3 mac is really a hot Mac FLV to MP3 Converting software which can extract MP3 from FLV files and convert FLV videos to various video and audio formats on Mac without interruption, including avi, mov, mpeg, wmv, mp4, etc, which are compatible video formats for iPod, iPhone, PSP, Zune, Xbox, and so forth. Apart from convert flv to mp3 on Mac, FLV to MP3 Mac provides you powerful editing functions, such as trimming videos, cropping videos, applying various effects, customizing video settings and personallizing watermark, as well. http://www.flvtomp4mac.com FLV to MP4 Mac Ideal and all-in-one mac video converter can easily and fastly help mac users to convert various video formats from one to another with perfect output quality and high conversion speed, including AVI, MPEG, WMV, FLV, MP4, H.264/MPEG-4, DivX, XviD, MOV, RM, ASF, 3GP, 3G2, VOB, TS, DV,H.264/MPEG-4 AVC (*.mp4). FLV to WMV Converter Mac OS X is a powerful converting tool.http://www.flvconvertermac.net/flv-to-wmv-mac.html FLV to WMV mac It can convert FLV to WMV Mac OS X automatically. Now, let's start to use the new FLV to WMV Mac Converter step-by-step . VOB to AVI Mac is currently the best converter so far for Mac users to convert VOB to AVI Mac fluently,[url=http://www.vobtoavimac.com]VOB to AVI Mac and it is an absolutely tailor to users' needs.

HEDRY

DFGHJKKLL;

Sunday, November 27, 2011

Omega http://www.new-watch-replica.com/41-omega was created by the Louis Brandt. Since 1848,it has been to create the glorious history in the watch industry.It became the first Swiss watch industry's manufacturers in 1900.From 1919 to now ,it keep a the World record about Observatory accuracy record.It provides timing services for 22 times in the Olympic Games and other international grand sports events such as athletics, swimming, golf and sailing competitions.In space expedition history, the Omega Speedmaster Professional was selected by the NASA in 1965.On 21th,July,1969,Human was landing on the moon, the astronauts on the moon who landed on the first step is wear the omega with Speedmaster Professional Chronograph. In 1970, when the Apollo 13 launch that Performing the task went wrong, the Speedmaster Professional Chronograph plyed a key role in accurate calculation of the engine ignition timing, so that the spacecraf returned into Earth orbit and "saved" the astronauts and spacecraft. International Space Station is also equipped with the latest X-33 Speedmaster Professional Chronograph.So,omega become a pioneer in the human conquest of space, once again .The design of this Omega watch consulted the United States, the Soviet Union and Europe as well as professional astronauts pilot professional, and featured with the most advanced technology, in order to fully meet the stringent professional requirements in aerospace mission. At the same time, Omega Speedmaster Professional Chronograph is the partners with United States and Russian . It will Walk with them into space.Here are many watches replica http://www.new-watch-replica.com ,such as Omega.Welcome to our watch online shop.

china wholesale

[email protected]

Wednesday, October 12, 2011

Industrial Supplies Wholesale Cap <h1><strong><a href="http://www.chinawholesaletown.com/wholesale-Voice-Recorder/"><b>Voice Recorder</b></a></strong></h1> Business Gift Wholesale Bedding <h1><strong><a href="http://www.chinawholesaletown.com/wholesale-Silicone-Bakeware/"><b>Silicone Bakeware</b></a></strong></h1> Personal Safety Products Wholesale Golf Products Flash Gift <h1><strong><a href="http://www.chinawholesaletown.com/wholesale-Writing-Instrument/"><b>Writing Instrument</b></a></strong></h1> Arts Crafts Garden Decorations Wholesale Speakers <h1><strong><a href="http://www.chinawholesaletown.com/wholesale-Bag/"><b>Wholesale Bag</b></a></strong></h1> Wholesale Frisbee CD Holde Wholesale Dartboard <h1><strong><a href="http://www.chinawholesaletown.com/"><b>Promotional Items</b></a><strong></h1> Electrical Gifts Valentine Gifts Wholesale Halloween Gift <h1><strong><a href="http://www.chinawholesaletown.com/wholesale-Tie/"><b>Wholesale Tie</b></a></strong></h1> Muslim Products Wholesale Frisbee Garden Decorations <h1><strong><a href="http://www.chinawholesaletown.com/"><b>Promotional Gifts</b></a><strong></h1> Wholesale Scarf Wholesale Tableware Vocal Concert Products <h1><strong><a href="http://www.chinawholesaletown.com/wholesale-Bracelet---Bangle/"><b>Wholesale Bangle</b></a></strong></h1> Lighting Products Wholesale Furniture Christmas Gifts <h1><strong><a href="http://www.chinawholesaletown.com/wholesale-Swimming/"><b>Wholesale Swimming Products</b></a></strong></h1> Beauty Equipment

We reserve the right to delete or edit any comments we find inappropriate.
Copyright © 1989 to 2011 by [LaPrensa Publications Inc.]. All rights reserved.
Revised: 10/26/12 18:21:37 -0700.